Иващенко В.В.

Objective. Experimental study of the effect of sodium hypochlorite (SH) on renal function and hormonal status intact rats, influencing the composition of the final urine.

The aim of the research. Experimental study of the sodium hypochlorite (SH) effect on the blood and urine electrolyte composition, cations and anions, that are part of the urinary stones, which are recognized risk factors for urolithiasis.

In this review we analyze the role of exogenic and endogenic risk factors of nephrolithiasis and their link to dysfunction of renal tubules and discuss cell membrane pathology, lipid peroxidation, ischemia and hypoxia of the kidneys, as well as hormonal balance and renal innervation with regard to urine lithogenic properties.

This article is devoted to the description of the method of extracorporeal indirect electrochemical oxidation (EIEBO) in patients with infectious inflammatory complications and grade I endotoxicosis. The distinguishing feature of the EIEBO from the adopted intracorporeal method of oxidation is that blood is being processed using 0.06% solution of the sodium hypochlorite (SH) within the venous extracorporeal line, created using special equipment.

This article is devoted to the prognostic method, which can show, whether if the urological infection will have a lethal or favorable outcome.

In this study we have investigated the influence of sodium hypochlorite (SH) on the blood leukocytes in rats (experimental part) and the possible applications of SH in patients with acute pyelonephritis. Experimental part was performed on 35 white inbreed male rats. Clinical part included 2 groups of patients from urological clinic.

Our article is devoted to the definitions of “stress”, “systemic inflammatory response syndrome” and to their equivalence. A new definition of “SIRS-stress reaction” was proposed to clearly depict the essence of the clinical and pathological processes in urological patients with acute inflammatory conditions.

The paper is dedicated to the mechanism of adaptogenic effect of sodium hypochlorite (SH). The studies were performed in three groups of 45 albino male rats. Group of intact animals were 5 rats. The rats in the control group (n = 20) were daily intraperitoneally (i / p) administered for 1.5 ml of saline for 4 days. The rats in the experimental group (n = 20) were similarly injected with 1.5 ml 0.06% solution of SH. The results in the group of intact rats were considered the normal values.

The paper studies the adaptogenic properties of 0.06% sodium hypochlorite solution (SH). The study was conducted in three groups of 15 outbred male rats. Intact group was of 5 rats subjected to no influence. The control group consisted of 5 animals, they were injected intraperitoneally with 1 ml of a saline solution once a day for 4 days. The experimental group consisted of 5 rats, they were injected intraperitoneally with 1 ml of 0.06% solution of the SH daily for 4 days (1.5-1.8 mg / kg).

The paper is dedicated to study of mechanism of sodium hypochlorite effect on renal concentration function. In two experimental series we studied metabolism parameters and functional ability of kidneys of intact rats after parenteral administration of sodium hypochlorite (SH) solution and opportunities to enhance renal structural-functional tolerance to ischemia upon parenteral administration of 0,06% SH solution in preischemic period.